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Article

A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease.

Inflammatory bowel diseases - 1 Jan 2026

Shojaei Jeshvaghani Zahra, Argmann Carmen, de Vries Maaike H, van Es Johan H, Collen Lauren V, Kotlarz Daniel, Sveen Mia, Comella Phillip H, Snapper Scott B, Klein Christoph, Schadt Eric E, Clevers Hans, Mokry Michal, Kuijk Ewart, Nieuwenhuis Edward

Abstract excerpt

BACKGROUND: Pediatric Inflammatory Bowel Disease (IBD) is a chronic condition characterized by persistent intestinal inflammation in children. It often presents with distinct clinical phenotypes and is more frequently linked to rare monogenic variants affecting epithelial barrier function or mucosal immunity. Although over 100 genes are associated with monogenic IBD, their roles in the intestinal epithelium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41273131
DOI: 10.1093/ibd/izaf296
PMCID: PMC12759058

Genes

LRBA
STXBP2
BTK
IL10RA
LIFR
SERPINA1
TRNT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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