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Article

Integrative single-cell RNA-seq and spatial transcriptomics analyses reveal diverse apoptosis-related gene expression profiles in EGFR-mutated lung cancer.

Cell death & disease - 9 Aug 2024

Izumi Motohiro, Fujii Masanori, Kobayashi Ikei S, Ho Vivian, Kashima Yukie, Udagawa Hibiki, Costa Daniel B, Kobayashi Susumu S

Abstract excerpt

In EGFR-mutated lung cancer, the duration of response to tyrosine kinase inhibitors (TKIs) is limited by the development of acquired drug resistance. Despite the crucial role played by apoptosis-related genes in tumor cell survival, how their expression changes as resistance to EGFR-TKIs emerges remains unclear. Here, we conduct a comprehensive analysis of apoptosis-related genes, including BCL-2 and IAP family...

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Identifiers

PMID: 39122703
DOI: 10.1038/s41419-024-06940-y
PMCID: PMC11316060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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