Article

Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Epidermal growth factor receptor (EGFR)-targeted therapies have demonstrated variable and unpredictable clinical responses in triple negative breast cancer (TNBC). To elucidate the underlying mechanisms of this variability, we employ cellular barcoding and single-cell transcriptomics to reconstruct the subclonal dynamics of EGFR-amplified TNBC cells in response to afatinib, a tyrosine kinase inh...

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Literature Corpus work: 18ffe6b0-6451-5819-84d7-c05ba2e9109f
DOI: 10.1101/2023.04.04.535588

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