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Article

Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment

30 Mar 2015

Abstract excerpt

BACKGROUND: To understand the heterogeneous behaviors of individual cancer cells, it is essential to investigate gene expression levels as well as their divergence between different individual cells. Recent advances in next-generation sequencing-related technologies have enabled us to conduct a single-cell RNA-Seq analysis of a series of lung adenocarcinoma cell lines. RESULTS: We analyze a total of 336...

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PMID: 25887790
DOI: 10.1186/s13059-015-0636-y

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