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Article

EGFR TKI resistance in lung cancer cells using RNA sequencing and analytical bioinformatics tools.

Journal of biomolecular structure & dynamics - 1 Nov 2023

Howell Mark C, Green Ryan, Cianne Junior, Dayhoff Guy W, Uversky Vladimir N, Mohapatra Shyam, Mohapatra Subhra

Abstract excerpt

Epidermal Growth Factor Receptor (EGFR) signaling and EGFR mutations play key roles in cancer pathogenesis, particularly in the development of drug resistance. For the ∼20% of all non-small cell lung cancer (NSCLC) patients that harbor an activating mutation, EGFR tyrosine kinase inhibitors (TKIs) provide initial clinical responses. However, long-term efficacy is not possible due to acquired drug resistance....

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Share to Carcinoma, Non-Small-Cell Lung
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to ErbB Receptors

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Share to Protein Kinase Inhibitors

Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 36524419
DOI: 10.1080/07391102.2022.2153269
PMCID: PMC10272293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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