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Single-cell and spatial transcriptomics reveal a potential role of ATF3 in brain metastasis of lung adenocarcinoma

1 Jan 2025

Abstract excerpt

Background: Brain metastasis (BrM) has been a challenge for lung cancer treatment, but the mechanisms underlying lung cancer BrM remain elusive. This study aims to dissect cellular components and their spatial distribution in human BrM tumors of lung adenocarcinoma (LUAD) and identify potential therapeutic targets. Methods: We performed single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) on...

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PMID: 39958219
DOI: 10.21037/tlcr-24-784

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