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Article

Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations.

PloS one - 21 Nov 2007

Choi Kuicheon, Creighton Chad J, Stivers David, Fujimoto Nobukazu, Kurie Jonathan M

Abstract excerpt

BACKGROUND: Activating somatic mutations in epidermal growth factor receptor (EGFR) confer unique biologic features to non-small cell lung cancer (NSCLC) cells, but the transcriptional mediators of EGFR in this subgroup of NSCLC have not been fully elucidated. METHODOLOGY/PRINCIPAL FINDINGS: Here we used genetic and pharmacologic approaches to elucidate the transcriptomes of NSCLC cell lines. We transcriptionally...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18030354
DOI: 10.1371/journal.pone.0001226
PMCID: PMC2080626

Genes

EGFR
PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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