MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.

doi:10.1038/s41467-020-18372-1

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Article

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.

Nature communications - 10 Sept 2020

Munkhbaatar Enkhtsetseg, Dietzen Michelle, Agrawal Deepti, Anton Martina, Jesinghaus Moritz, Boxberg Melanie, Pfarr Nicole, Bidola Pidassa, Uhrig Sebastian, Höckendorf Ulrike, Meinhardt Anna-Lena, Wahida Adam, Heid Irina, Braren Rickmer, Mishra Ritu, Warth Arne, Muley Thomas, Poh Patrina S P, Wang Xin, Fröhling Stefan, Steiger Katja, Slotta-Huspenina Julia, van Griensven Martijn, Pfeiffer Franz, Lange Sebastian, Rad Roland, Spella Magda, Stathopoulos Georgios T, Ruland Jürgen, Bassermann Florian, Weichert Wilko, Strasser Andreas, Branca Caterina, Heikenwalder Mathias, Swanton Charles, McGranahan Nicholas, Jost Philipp J

Abstract excerpt

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning cancer cell survival despite the oncogenic stress could provide a molecular basis for potential therapeutic interventions. Here we explore the role of pro-survival genes in cancer cell integrity during clonal evolution in non-small cell lung cancer (NSCLC). We...

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PMID: 32913197
DOI: 10.1038/s41467-020-18372-1
PMCID: PMC7484793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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