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Article

Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells.

Genome biology - 19 Jun 2015

Kim Kyu-Tae, Lee Hye Won, Lee Hae-Ock, Kim Sang Cheol, Seo Yun Jee, Chung Woosung, Eum Hye Hyeon, Nam Do-Hyun, Kim Junhyong, Joo Kyeung Min, Park Woong-Yang

Abstract excerpt

BACKGROUND: Intra-tumoral genetic and functional heterogeneity correlates with cancer clinical prognoses. However, the mechanisms by which intra-tumoral heterogeneity impacts therapeutic outcome remain poorly understood. RNA sequencing (RNA-seq) of single tumor cells can provide comprehensive information about gene expression and single-nucleotide variations in individual tumor cells, which may allow for the...

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

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Share to Tumor Cells, Cultured

Share to Xenograft Model Antitumor Assays

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Identifiers

PMID: 26084335
DOI: 10.1186/s13059-015-0692-3
PMCID: PMC4506401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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