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Article

Polygenic Risk and Coronary Artery Disease Severity.

Circulation. Genomic and precision medicine - 1 Oct 2024

Sherafati Alborz, Norland Kristjan, Naderian Mohammadreza, Schaid Daniel J, Kullo Iftikhar J

Abstract excerpt

BACKGROUND: Coronary atherosclerotic burden and adverse coronary heart disease events are related phenotypes with likely shared genetic cause. METHODS: We analyzed 6021 patients with available coronary angiography, genotyping, and exome sequencing data. We tested for associations of polygenic risk scores for coronary heart disease (PRSCHD) with multiple measures of coronary artery disease (CAD) severity. We...

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PMID: 39114909
DOI: 10.1161/CIRCGEN.123.004470

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