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Article

Polygenic risk for coronary heart disease acts through atherosclerosis in type 2 diabetes.

Cardiovascular diabetology - 30 Jan 2020

Lu Tianyuan, Forgetta Vincenzo, Yu Oriana H Y, Mokry Lauren, Gregory Madeline, Thanassoulis George, Greenwood Celia M T, Richards J Brent

Abstract excerpt

BACKGROUND: Type 2 diabetes increases the risk of coronary heart disease (CHD), yet the mechanisms involved remain poorly described. Polygenic risk scores (PRS) provide an opportunity to understand risk factors since they reflect etiologic pathways from the entire genome. We therefore tested whether a PRS for CHD influenced risk of CHD in individuals with type 2 diabetes and which risk factors were associated...

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Identifiers

PMID: 32000781
DOI: 10.1186/s12933-020-0988-9
PMCID: PMC6993460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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