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Article

Cysteine oxidation and disulfide formation in the ribosomal exit tunnel.

Nature communications - 4 Nov 2020

Schulte Linda, Mao Jiafei, Reitz Julian, Sreeramulu Sridhar, Kudlinzki Denis, Hodirnau Victor-Valentin, Meier-Credo Jakob, Saxena Krishna, Buhr Florian, Langer Julian D, Blackledge Martin, Frangakis Achilleas S, Glaubitz Clemens, Schwalbe Harald

Abstract excerpt

Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate the eye-lens protein γB-crystallin in the ribosomal exit tunnel. Using mass spectrometry, theoretical simulations,...

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Identifiers

PMID: 33149120
DOI: 10.1038/s41467-020-19372-x
PMCID: PMC7642426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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