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Article

Energetically significant networks of coupled interactions within an unfolded protein.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2014

Cho Jae-Hyun, Meng Wenli, Sato Satoshi, Kim Eun Young, Schindelin Hermann, Raleigh Daniel P

Abstract excerpt

Unfolded and partially unfolded proteins participate in a wide range of biological processes from pathological aggregation to the regulation of normal cellular activity. Unfolded states can be populated under strongly denaturing conditions, but the ensemble which is relevant for folding, stability, and aggregation is that populated under physiological conditions. Characterization of nonnative states is critical...

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PMID: 25099351
DOI: 10.1073/pnas.1402054111
PMCID: PMC4143010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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