Article
Large-scale discovery, analysis and design of protein energy landscapes.
Nature - 1 Jun 2026
Ferrari Állan J R, Dixit Sugyan M, Thibeault Jane, Garcia Mario, Houliston Scott, Ludwig Robert W, Notin Pascal, Phoumyvong Claire M, Martell Cydney M, Jung Michelle D, Tsuboyama Kotaro, Carter Lauren, Arrowsmith Cheryl H, Guttman Miklos, Rocklin Gabriel J
Abstract excerpt
All folded proteins continuously fluctuate between their low-energy native structures and higher-energy conformations that can be partially or fully unfolded. These rare states influence protein function1,2, interactions3, aggregation4-7 and immunogenicity8,9, yet they remain far less understood than protein native states. Although native protein structures are now often predictable with impressive accuracy,...
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