Article

The folding and unfolding behavior of ribonuclease H on the ribosome

2020-04-18

Abstract excerpt

<h4>ABSTRACT</h4> The health of a cell depends on accurate translation and proper protein folding; misfolding can lead to aggregation and disease. The first opportunity for a protein to fold occurs during translation, when the ribosome and surrounding environment can affect the energy landscape of the nascent chain. However, quantifying these environmental effects is challenging due to the ribosomal proteins and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 236b5619-4539-58af-8557-51c8b967a217
DOI: 10.1101/2020.04.16.044867

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The folding and unfolding behavior of ribonuclease H on the ribosomeDOI 10.1101/2020.04.16.044867Read

The ribosome lowers the entropic penalty of protein folding.Semantic proximity Read

A single mutation at residue 25 populates the folding intermediate of E. coli RNase H and reveals a highly dynamic partially folded ensemble.Semantic proximity Read

mRNA stem-loops can pause the ribosome by hindering A-site tRNA bindingSemantic proximity Read

Comparison of the folding processes of T. thermophilus and E. coli ribonucleases H.Semantic proximity Read

Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.Semantic proximity Read

Unfolded proteins and protein folding studied by NMR.Semantic proximity Read

Selective inhibition of human translation by a drug-like compound that traps terminated protein nascent chains on the ribosomeSemantic proximity Read

Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like moleculeSemantic proximity Read

Hibernation factors directly block ribonucleases from entering the ribosome in response to starvation.Semantic proximity Read

Backbone-driven collapse in unfolded protein chains.Semantic proximity Read

Localized ribosome access and distal tuning via the <i>Listeria prfA</i> RNA thermometerSemantic proximity Read

The folding trajectory of RNase H is dominated by its topology and not local stability: a protein engineering study of variants that fold via two-state and three-state mechanisms.Semantic proximity Read