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Article

Cotranslational response to proteotoxic stress by elongation pausing of ribosomes.

Molecular cell - 7 Feb 2013

Liu Botao, Han Yan, Qian Shu-Bing

Abstract excerpt

Translational control permits cells to respond swiftly to a changing environment. Rapid attenuation of global protein synthesis under stress conditions has been largely ascribed to the inhibition of translation initiation. Here we report that intracellular proteotoxic stress reduces global protein synthesis by halting ribosomes on transcripts during elongation. Deep sequencing of ribosome-protected messenger RNA...

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Identifiers

PMID: 23290916
DOI: 10.1016/j.molcel.2012.12.001
PMCID: PMC3570626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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