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Article

Activation mechanism and novel binding sites of the BKCa channel activator CTIBD.

Life science alliance - 1 Oct 2024

Lee Narasaem, Kim Subin, Lee Na Young, Jo Heeji, Jeong Pyeonghwa, Pagire Haushabhau S, Pagire Suvarna H, Ahn Jin Hee, Jin Mi Sun, Park Chul-Seung

Abstract excerpt

The large-conductance calcium-activated potassium (BKCa) channel, which is crucial for urinary bladder smooth muscle relaxation, is a potential target for overactive bladder treatment. Our prior work unveiled CTIBD as a promising BKCa channel activator, altering V 1/2 and G max This study investigates CTIBD's activation mechanism, revealing its independence from the Ca2+ and membrane voltage sensing of the BKCa...

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Calcium
Chloride Channel Agonists
Cryoelectron Microscopy
HEK293 Cells
Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Large-Conductance Calcium-Activated Potassium Channel alpha Subunits

Large-Conductance Calcium-Activated Potassium Channels

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Identifiers

PMID: 39089879
DOI: 10.26508/lsa.202402621
PMCID: PMC11294680

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