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Article

Trikafta rescues F508del-CFTR by tightening specific phosphorylation-dependent interdomain interactions

2024-11-21

Abstract excerpt

Trikafta effectively corrects the thermal and gating defects associated with the F508del mutation, the most common cause of cystic fibrosis, even at physiological temperatures. However, the exact correction pathway is still unclear. Here, noncovalent interactions among two transmembrane domains (TMD1 and TMD2), the regulatory (R) domain and two nucleotide binding domains (NBD1 and NBD2) were analyzed. The thermal...

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Identifiers and source

Literature Corpus work
57ad0ef8-6796-5973-bd4d-1b7ea3c5710f
DOI
10.1101/2024.11.20.624197
Open publication

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Trikafta rescues F508del-CFTR by tightening specific phosphorylation-dependent interdomain interactionsDOI 10.1101/2024.11.20.624197
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