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Human T-cell receptor triggering requires inactivation of Lim kinase-1 by Slingshot-1 phosphatase

30 Jul 2024

Abstract excerpt

Actin dynamics control early T-cell receptor (TCR) signalling during T-cell activation. However, the precise regulation of initial actin rearrangements is not completely understood. Here, we have investigated the regulatory role of the phosphatase Slingshot-1 (SSH1) in this process. Our data show that SSH1 rapidly polarises to nascent cognate synaptic contacts and later relocalises to peripheral F-actin networks...

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PMID: 39080357
DOI: 10.1038/s42003-024-06605-8

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