Article
A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
Molecular cell - 3 Aug 2017
Courtney Adam H, Amacher Jeanine F, Kadlecek Theresa A, Mollenauer Marianne N, Au-Yeung Byron B, Kuriyan John, Weiss Arthur
Abstract excerpt
The Src Family kinase Lck sets a critical threshold for T cell activation because it phosphorylates the TCR complex and the Zap70 kinase. How a T cell controls the abundance of active Lck molecules remains poorly understood. We have identified an unappreciated role for a phosphosite, Y192, within the Lck SH2 domain that profoundly affects the amount of active Lck in cells. Notably, mutation of Y192 blocks...
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