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Article

A pleckstrin homology-like domain is critical for F-actin binding and cofilin-phosphatase activity of Slingshot-1.

Biochemical and biophysical research communications - 22 Jan 2017

Takahashi Katsunori, Okabe Haruka, Kanno Shin-Ichiro, Nagai Tomoaki, Mizuno Kensaku

Abstract excerpt

Slingshot-1 (SSH1) is a protein phosphatase that specifically dephosphorylates and activates cofilin, an F-actin-severing protein. SSH1 binds to and co-localizes with F-actin, and the cofilin-phosphatase activity of SSH1 is markedly increased by binding to F-actin. In this study, we performed a secondary structure analysis of SSH1, which predicted the existence of a pleckstrin homology (PH)-like domain in the...

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Source

Identifiers

PMID: 27865840
DOI: 10.1016/j.bbrc.2016.11.095

Genes

SSH1
DEK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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