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Article

Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.

Cancer research - 15 Jul 2009

Peterburs Philipp, Heering Johanna, Link Gisela, Pfizenmaier Klaus, Olayioye Monilola A, Hausser Angelika

Abstract excerpt

Protein kinase D (PKD) has been identified as a negative regulator of epithelial cell migration; however, its molecular substrates and downstream signaling pathways that mediate this activity have remained elusive. In this study, we provide evidence that the cofilin phosphatase slingshot 1 like (SSH1L), an important regulator of the complex actin remodeling machinery, is a novel in vivo PKD substrate....

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PMID: 19567672
DOI: 10.1158/0008-5472.CAN-09-0718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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