Article
A THEMIS:SHP1 complex promotes T-cell survival.
The EMBO journal - 3 Feb 2015
Paster Wolfgang, Bruger Annika M, Katsch Kristin, Grégoire Claude, Roncagalli Romain, Fu Guo, Gascoigne Nicholas R J, Nika Konstantina, Cohnen Andre, Feller Stephan M, Simister Philip C, Molder Kelly C, Cordoba Shaun-Paul, Dushek Omer, Malissen Bernard, Acuto Oreste
Abstract excerpt
THEMIS is critical for conventional T-cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates with the phosphatases SHP1 and SHP2. This complex requires the adapter GRB2, which bridges SHP to THEMIS in a Tyr-phosphorylation-independent fashion. Rather, SHP1 and THEMIS engage with the N-SH3 and C-SH3 domains of GRB2, respectively, a configuration...
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