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Article

The adapter protein Nck: Role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes

15 Jan 2010

Abstract excerpt

Nck is a ubiquitously expressed, primarily cytosolic adapter protein consisting of one SH2 domain and three SH3 domains. It links receptor and nonreceptor tyrosine kinases to actin cytoskeleton reorganizing proteins. In T lymphocytes, Nck is a crucial component of signaling pathways for T cell activation and effector function. It recruits actin remodeling proteins to T cell receptor (TCR)-associated activation...

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PMID: 20082308
DOI: 10.1002/pro.334

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