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Article

Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine

30 Jul 2024

Abstract excerpt

The rodent-borne Andes virus (ANDV) causes a severe disease in humans. We developed an ANDV mRNA vaccine based on the M segment of the viral genome, either with regular uridine (U-mRNA) or N1-methylpseudouridine (m1Ψ-mRNA). Female mice immunized by m1Ψ-mRNA developed slightly greater germinal center (GC) responses than U-mRNA-immunized mice. Single cell RNA and BCR sequencing of the GC B cells revealed similar...

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PMID: 39080316
DOI: 10.1038/s41467-024-50774-3

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