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Article

Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in Mice

20 Jul 2020

Abstract excerpt

Dengue virus (DENV) infection is a major global public health concern, and there is no effective vaccine for it. In this study, we describe the design and characterization of three nucleotide-modified mRNA vaccines (prME-mRNA, E80-mRNA, and NS1-mRNA) for DENV-2. Our results showed that vaccination with E80-mRNA alone or a combination of E80-mRNA and NS1-mRNA can induce high levels of neutralizing antibodies and...

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PMID: 32913878
DOI: 10.1016/j.omtm.2020.07.013

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