Article

Andes virus mRNA vaccines: comparison of unmodified and modified mRNA platforms

2023-08-10

Abstract excerpt

<title>Abstract</title> <p>Andes virus (ANDV) is a rodent-borne zoonotic orthohantavirus endemic in South America that causes hantavirus pulmonary syndrome in humans, with up to a 40% case fatality rate. We developed ANDV mRNA vaccines based on the M segment of the viral genome that codes for glycoproteins Gn and Gc in a single open reading frame of glycoprotein precursor (GPC). We generated RNAs either with regu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e0fdb42-518f-5254-81df-7371251adc5b
DOI: 10.21203/rs.3.rs-3182841/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Andes virus mRNA vaccines: comparison of unmodified and modified mRNA platformsDOI 10.21203/rs.3.rs-3182841/v1Read

Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccineSemantic proximity Read

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strainsSemantic proximity Read

mRNA Vaccines against FlavivirusesSemantic proximity Read

Current Developments and Challenges of mRNA VaccinesSemantic proximity Read

Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primatesSemantic proximity Read

Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical modelsSemantic proximity Read

mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2Semantic proximity Read

Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in MiceSemantic proximity Read

Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studiesSemantic proximity Read

mRNA cancer vaccines: Advances, trends and challengesSemantic proximity Read

Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and HumansSemantic proximity Read

Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2Semantic proximity Read