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Article

Construction and Nonclinical Testing of a Puumala Virus Synthetic M Gene-Based DNA Vaccine

13 Dec 2012

Abstract excerpt

Puumala virus (PUUV) is a causative agent of hemorrhagic fever with renal syndrome (HFRS). Although PUUV-associated HFRS does not result in high case-fatality rates, the social and economic impact is considerable. There is no licensed vaccine or specific therapeutic to prevent or treat HFRS. Here we report the synthesis of a codon-optimized, full-length M segment open reading frame and its cloning into a DNA...

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PMID: 23239797
DOI: 10.1128/cvi.00546-12

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