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A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus

5 Feb 2025

Abstract excerpt

The Food and Drug Administration (FDA) has approved vaccines designed by GSK, Pfizer and Moderna to protect high-risk populations against respiratory syncytial virus (RSV). These vaccines employ the pre-fusion F (pre-F) protein as the immunogen. In this study, we explored an mRNA vaccine based on a modified pre-F protein called LC2DM-lipid nanoparticle (LC2DM-LNP). This vaccine features a truncated version of the...

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PMID: 39910047
DOI: 10.1038/s41467-025-56302-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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