Article

Novel mRNA-based VP8* vaccines against rotavirus are highly immunogenic in rodents

2023-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Despite the availability of live-attenuated oral vaccines, rotavirus remains a major cause of severe childhood diarrhea worldwide. Due to the growing demand for parenteral rotavirus vaccines, we developed novel mRNA-based vaccine candidates targeting the viral spike protein VP8*. Our monomeric P2 (universal T cell epitope)-VP8* mRNA design is equivalent to a protein vaccine currently in clinical...

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Literature Corpus work: bea7101b-941f-5bbf-9868-35a107d63add
DOI: 10.1101/2023.03.29.534747

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