Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations in the expression of homologous recombination repair (HRR) genes in breast cancer tissues considering germline BRCA1/2 mutation status.

Breast cancer research and treatment - 1 Dec 2024

Laczmanska Izabela, Matkowski Rafal, Supplitt Stanislaw, Karpinski Pawel, Abrahamowska Mariola, Laczmanski Lukasz, Maciejczyk Adam, Czykalko Ewelina, Iwaneczko Ewelina, Kasprzak Piotr, Szynglarewicz Bartłomiej, Sasiadek Maria

Abstract excerpt

INTRODUCTION: Homologous recombination (HR) is a crucial DNA-repair mechanism, and its disruption can lead to the accumulation of mutations that initiate and promote cancer formation. The key HR genes, BRCA1 and BRCA2, are particularly significant as their germline pathogenic variants are associated with a hereditary predisposition to breast and/or ovarian cancer. MATERIALS AND METHODS: The study was performed on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Breast Neoplasms

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Recombinational DNA Repair

Source

Open in PubMed Open full text

Identifiers

PMID: 39080120
DOI: 10.1007/s10549-024-07441-4
PMCID: PMC11522089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in the expression of homologous recombination repair (HRR) genes in breast cancer tissues considering germline BRCA1/2 mutation status.PMID 39080120Read ↗

Mutations of TP53 and genes related to homologous recombination repair in breast cancer with germline BRCA1/2 mutationsSemantic proximity Read ↗

Mutations of TP53 and genes related to homologous recombination repair in breast cancer with germline BRCA1/2 mutations.Semantic proximity Read ↗

Homologous repair deficiency score for identifying breast cancers with defective DNA damage responseSemantic proximity Read ↗

Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.Semantic proximity Read ↗

Homologous Recombination Deficiency Among Patients with Germline or Somatic non-BRCA1/2 Homologous Recombination Repair Gene VariationsSemantic proximity Read ↗

Hereditary breast cancer: from molecular pathology to tailored therapies.Semantic proximity Read ↗

Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variationsSemantic proximity Read ↗

The Fanconi anemia pathway and Breast Cancer: A comprehensive review of clinical data.Semantic proximity Read ↗

The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.Semantic proximity Read ↗

Landscape of DNA damage response gene alterations in breast cancer: A comprehensive investigation.Semantic proximity Read ↗

BRCA1/2 signaling and homologous recombination deficiency in breast and ovarian cancer.Semantic proximity Read ↗

Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.