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Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variations

17 Jun 2025

Abstract excerpt

This study examined the relationship between homologous recombination deficiency (HRD) and variations in non-BRCA1/2 homologous recombination repair (HRR) genes. 27.3% (132/483) of the patients with ovarian, breast, endometrial, prostate, and pancreatic cancers carrying non-BRCA1/2 HRR variations were HRD + . Germline mutations were associated with significantly higher HRD+ rates than somatic mutations, while...

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PMID: 40527918
DOI: 10.1038/s41698-025-00999-2

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