Article
BRCA1/2 signaling and homologous recombination deficiency in breast and ovarian cancer.
Future oncology (London, England) - 1 Jul 2021
Royfman Rachel, Whiteley Emma, Noe Olivia, Morand Susan, Creeden Justin, Stanbery Laura, Hamouda Danae, Nemunaitis John
Abstract excerpt
Patients who have mutations of the genes BRCA1 or BRCA2 are at an increased risk for developing breast and ovarian cancer. BRCA1/2 function as tumor suppressor genes, responsible for regulating DNA repair, and play an essential role in homologous recombination. Mutation of BRCA1/2 results in homologous recombination deficiency and genomic instability which drives oncogenesis and cancer proliferation. Recently,...
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