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Landscape of DNA damage response gene alterations in breast cancer: A comprehensive investigation.

Cancer - 15 Mar 2023

Jin Juan, Cao Jianing, Li Bin, Li Ting, Zhang Jian, Cao Jun, Zhao Mingchun, Wang Leiping, Wang Biyun, Tao Zhonghua, Hu Xichun

Abstract excerpt

BACKGROUND: DNA damage response (DDR) gene alterations are prevalent in breast cancer (BC) and important for treatment decisions. Intensive studies on DDR alterations in BC are still needed. METHODS: The authors included 438 patients with metastatic breast cancer from their next-generation sequencing database and 1091 patients with early-stage breast cancer from The Cancer Genome Atlas (TCGA) database in the...

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PMID: 36655350
DOI: 10.1002/cncr.34618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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