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Mutations of TP53 and genes related to homologous recombination repair in breast cancer with germline BRCA1/2 mutations.

Human genomics - 6 Jan 2023

Kim Jinyong, Jeong Kyeonghun, Jun Hyeji, Kim Kwangsoo, Bae Jeong Mo, Song Myung Geun, Yi Hanbaek, Park Songyi, Woo Go-Un, Lee Dae-Won, Kim Tae-Yong, Lee Kyung-Hun, Im Seock-Ah

Abstract excerpt

BACKGROUND: Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 (gBRCA1/2) are associated with elevated risk of breast cancer in young women in Asia. BRCA1 and BRCA2 proteins contribute to genomic stability through homologous recombination (HR)-mediated double-strand DNA break repair in cooperation with other HR-related proteins. In this study, we analyzed the targeted sequencing data of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36604691
DOI: 10.1186/s40246-022-00447-3
PMCID: PMC9817339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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