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Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

5 Oct 2017

Abstract excerpt

BRCA1 and BRCA2 are involved in homologous recombination (HR) DNA repair and are germ-line cancer pre-disposition genes that result in a syndrome of hereditary breast and ovarian cancer (HBOC). Whether germ-line or somatic alterations in these genes or other members of the HR pathway and if mono- or bi-allelic alterations of HR-related genes have a phenotypic impact on other cancers remains to be fully...

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PMID: 29021619
DOI: 10.1038/s41467-017-00921-w

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