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Article

Hereditary breast cancer: from molecular pathology to tailored therapies.

Journal of clinical pathology - 1 Oct 2008

Tan D S P, Marchiò C, Reis-Filho J S

Abstract excerpt

Hereditary breast cancer accounts for up to 5-10% of all breast carcinomas. Recent studies have demonstrated that mutations in two high-penetrance genes, namely BRCA1 and BRCA2, are responsible for about 16% of the familial risk of breast cancer. Even though subsequent studies have failed to find another high-penetrance breast cancer susceptibility gene, several genes that confer a moderate to low risk of breast...

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Source

Identifiers

PMID: 18682420
DOI: 10.1136/jcp.2008.057950

Genes

BRCA1
BRCA2
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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