Article

Mutations of TP53 and genes related to homologous recombination repair in breast cancer with germline BRCA1/2 mutations

2022-08-16

Abstract excerpt

<h4>Background: </h4> Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 ( gBRCA1/2 ) are associated with elevated risk of breast cancer in young women in Asia. BRCA1 and BRCA2 proteins contribute to genomic stability through homologous recombination (HR)-mediated double strand DNA break repair in cooperation with other HR-related proteins. In this study, we analyzed the targeted sequencing da...

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Literature Corpus work: 63b0e841-eeeb-54f6-a211-56704313436c
DOI: 10.21203/rs.3.rs-1942928/v1

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