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Homologous repair deficiency score for identifying breast cancers with defective DNA damage response

27 Jul 2020

Abstract excerpt

Breast cancer (BC) in patients with germline mutations of BRCA1/BRCA2 are associated with benefit from drugs targeting DNA damage response (DDR), but they account for only 5-7% of overall breast cancer. To define the characteristics of these tumors and also to identify tumors without BRCA mutation but with homologous recombination deficiency (HRD) is clinically relevant. To define characteristic features of HRD...

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PMID: 32719318
DOI: 10.1038/s41598-020-68176-y

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