Back to search

Article

Single-subject Proteomic Signatures in Alzheimer’s Disease Reflect Clinical Phenotypes and Distinguish Asymptomatic from Symptomatic Cases

2026-02-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Alzheimer’s Disease (AD) exhibits considerable inter-individual variability in clinical presentation, neuropathological burden, and underlying molecular processes. Conventional cohort-based analyses of omics molecular data often mask individual-level heterogeneity, limiting insights into the precision therapeutic strategies. To address this challenge, we developed INDIGO (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
776c987f-808b-5b39-a706-0c8a25564788
DOI
10.64898/2026.02.06.704408
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-subject Proteomic Signatures in Alzheimer’s Disease Reflect Clinical Phenotypes and Distinguish Asymptomatic from Symptomatic CasesDOI 10.64898/2026.02.06.704408
Genetic and Multi-omic Risk Assessment of Alzheimer’s Disease Implicates Core Associated Biological DomainsSemantic proximity
Genetic and multi‐omic risk assessment of Alzheimer's disease implicates core associated biological domainsSemantic proximity
Proteomic Signatures of Neuropathological Alterations in Alzheimer’s Disease: Insights from the Bio-Hermes StudySemantic proximity
Genetic and Multi-omic Risk Assessment of Alzheimer’s Disease Implicates Core Associated Biological DomainsSemantic proximity
Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneitySemantic proximity
Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer’s disease heterogeneitySemantic proximity
Proteomic Signatures of Neuropathological Alterations in Alzheimer’s Disease: Insights from the Bio-Hermes StudySemantic proximity
Balanced deep learning on multi-omics networks identifies molecular subgroups of pathological brain agingSemantic proximity
Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discoverySemantic proximity
Human brain aging heterogeneity observed from multi-region omics data reveals a subtype closely related to Alzheimer’s diseaseSemantic proximity
Proteomic Network Analysis of Alzheimer’s Disease Cerebrospinal Fluid Reveals Alterations Associated with <i>APOE</i> ε4 Genotype and Atomoxetine TreatmentSemantic proximity
Beyond the Genotype: A Multi-Omic Analysis of APOEe4’s Role in Alzheimer’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.