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Genomic Alterations and Clinical Characterization in Chinese Patients with Metastatic Colorectal Cancer.

Discovery medicine - 1 Jul 2024

Zhang Xu-Hui, Zhou Jie-Qiong, Wei Qing, Li Jian, Xu Ting, Bai Chun-Mei, Zhou Jian-Feng, Wang Xi-Cheng

Abstract excerpt

BACKGROUND: Metastatic colorectal cancer (mCRC) is increasingly characterized by myriad genomic alterations beyond the well-known factors such as RAS, BRAF, and microsatellite instability (MSI). Novel genomic changes, including ERBB2 amplifications, mutations, and gene fusions, are now recognized as potential targets for precision therapy. This study aims to explore the genomic landscape of a Chinese cohort with...

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PMID: 39054718
DOI: 10.24976/Discov.Med.202436186.137

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