Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine.

doi:10.1186/s13073-016-0387-8

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Article

Genomic landscape of colorectal cancer in Japan: clinical implications of comprehensive genomic sequencing for precision medicine.

Genome medicine - 22 Dec 2016

Nagahashi Masayuki, Wakai Toshifumi, Shimada Yoshifumi, Ichikawa Hiroshi, Kameyama Hitoshi, Kobayashi Takashi, Sakata Jun, Yagi Ryoma, Sato Nobuaki, Kitagawa Yuko, Uetake Hiroyuki, Yoshida Kazuhiro, Oki Eiji, Kudo Shin-Ei, Izutsu Hiroshi, Kodama Keisuke, Nakada Mitsutaka, Tse Julie, Russell Meaghan, Heyer Joerg, Powers Winslow, Sun Ruobai, Ring Jennifer E, Takabe Kazuaki, Protopopov Alexei, Ling Yiwei, Okuda Shujiro, Lyle Stephen

Abstract excerpt

BACKGROUND: Comprehensive genomic sequencing (CGS) has the potential to revolutionize precision medicine for cancer patients across the globe. However, to date large-scale genomic sequencing of cancer patients has been limited to Western populations. In order to understand possible ethnic and geographic differences and to explore the broader application of CGS to other populations, we sequenced a panel of 415...

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Identifiers

PMID: 28007036
DOI: 10.1186/s13073-016-0387-8
PMCID: PMC5180401

Genes

BRAF
ERBB2
KRAS
NRAS

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