Article
Performance validation of an amplicon-based targeted next-generation sequencing assay and mutation profiling of 648 Chinese colorectal cancer patients.
Virchows Archiv : an international journal of pathology - 1 Jun 2018
Wang Yajian, Liu Haijing, Hou Yingyong, Zhou Xiaoyan, Liang Li, Zhang Zhihong, Shi Huaiyin, Xu Sanpeng, Hu Peizhen, Zheng Zuyu, Liu Rui, Tang Tingdong, Ye Feng, Liang Zhiyong, Bu Hong
Abstract excerpt
Next-generation sequencing (NGS) has become a promising approach for tumor somatic mutation detection. However, stringent validation is required for its application on clinical specimens, especially for low-quality formalin-fixed paraffin-embedded (FFPE) tissues. Here, we validated the performance of an amplicon-based targeted NGS assay, OncoAim™ DNA panel, on both commercial reference FFPE samples and clinical...
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