Article
Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite Instability Status in Chinese Patients with Colorectal Cancer.
The oncologist - 1 Nov 2020
Guo Yun, Guo Xian-Ling, Wang Shuang, Chen Xinyu, Shi Jiaochun, Wang Jian, Wang Kai, Klempner Samuel J, Wang Weifeng, Xiao Min
Abstract excerpt
BACKGROUND: The increasing molecular characterization of colorectal cancers (CRCs) has spurred the need to look beyond RAS, BRAF, and microsatellite instability (MSI). Genomic alterations, including ERBB2 amplifications and mutations, POLE mutations, MSI, and NTRK1-3 fusions, have emerged as targets for matched therapies. We sought to study a clinically annotated Chinese cohort of CRC subjected to genomic...
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