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Article

Enzoology: understanding enzyme interactions and epistasis in the cell.

Trends in biochemical sciences - 1 Oct 2024

Savinov Andrew

Abstract excerpt

Recent work from Nguyen et al. unveils massively parallel measurements of epistatic interactions between two enzymes, dihydrofolate reductase and thymidylate synthase, in their natural cellular context. Almost 3000 mutations of DHFR in three TYMS backgrounds reveal a complex interaction network. The authors capture much of this complexity using a simple model.

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Source

Identifiers

PMID: 39048479
DOI: 10.1016/j.tibs.2024.07.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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