Article
A Quantitative Genetic Interaction Map of HIV Infection.
Molecular cell - 16 Apr 2020
Gordon David E, Watson Ariane, Roguev Assen, Zheng Simin, Jang Gwendolyn M, Kane Joshua, Xu Jiewei, Guo Jeffrey Z, Stevenson Erica, Swaney Danielle L, Franks-Skiba Kathy, Verschueren Erik, Shales Michael, Crosby David C, Frankel Alan D, Marson Alexander, Marazzi Ivan, Cagney Gerard, Krogan Nevan J
Abstract excerpt
We have developed a platform for quantitative genetic interaction mapping using viral infectivity as a functional readout and constructed a viral host-dependency epistasis map (vE-MAP) of 356 human genes linked to HIV function, comprising >63,000 pairwise genetic perturbations. The vE-MAP provides an expansive view of the genetic dependencies underlying HIV infection and can be used to identify drug targets and...
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