The genetic landscape of a metabolic interaction.

Abstract excerpt

While much prior work has explored the constraints on protein sequence and evolution induced by physical protein-protein interactions, the sequence-level constraints emerging from non-binding functional interactions in metabolism remain unclear. To quantify how variation in the activity of one enzyme constrains the biochemical parameters and sequence of another, we focus on dihydrofolate reductase (DHFR) and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mutation
• Share to Thymidylate Synthase