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Article

The simplicity of protein sequence-function relationships.

Nature communications - 11 Sept 2024

Park Yeonwoo, Metzger Brian P H, Thornton Joseph W

Abstract excerpt

How complex are the rules by which a protein's sequence determines its function? High-order epistatic interactions among residues are thought to be pervasive, suggesting an idiosyncratic and unpredictable sequence-function relationship. But many prior studies may have overestimated epistasis, because they analyzed sequence-function relationships relative to a single reference sequence-which causes measurement...

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Identifiers

PMID: 39261454
DOI: 10.1038/s41467-024-51895-5
PMCID: PMC11390738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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