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Article

Validation Strategy for Ultrasensitive Mutation Detection.

Molecular diagnosis & therapy - 1 Oct 2018

Debeljak Marija, Noë Michael, Riel Stacy L, Haley Lisa M, Norris Alexis L, Anderson Derek A, Adams Emily M, Suenaga Masaya, Beierl Katie F, Lin Ming-Tseh, Goggins Michael G, Gocke Christopher D, Eshleman James R

Abstract excerpt

BACKGROUND: Ultrasensitive detection of low-abundance DNA point mutations is a challenging molecular biology problem, because nearly identical mutant and wild-type molecules exhibit crosstalk. Reliable ultrasensitive point mutation detection will facilitate early detection of cancer and therapeutic monitoring of cancer patients. OBJECTIVE: The objective of this study was to develop a method to correct errors in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29974360
DOI: 10.1007/s40291-018-0350-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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