Article
PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression.
Genome medicine - 22 Jul 2024
Lee Yi Fei, Phua Cheryl Zi Jin, Yuan Ju, Zhang Bin, Lee May Yin, Kannan Srinivasaraghavan, Chiu Yui Hei Jasper, Koh Casslynn Wei Qian, Yap Choon Kong, Lim Edwin Kok Hao, Chen Jianbin, Lim Yuhua, Lee Jane Jia Hui, Skanderup Anders Jacobsen, Wang Zhenxun, Zhai Weiwei, Tan Nguan Soon, Verma Chandra S, Tay Yvonne, Tan Daniel Shao Weng, Tam Wai Leong
Abstract excerpt
BACKGROUND: The identification of cancer driver genes from sequencing data has been crucial in deepening our understanding of tumor biology and expanding targeted therapy options. However, apart from the most commonly altered genes, the mechanisms underlying the contribution of other mutations to cancer acquisition remain understudied. Leveraging on our whole-exome sequencing of the largest Asian lung...
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